Tadalafil

This formulation combines three active compounds — tadalafil, bremelanotide and pregnenolone — in a single physician-compounded preparation. Tadalafil is a PDE5 inhibitor: it blocks the phosphodiesterase type 5 enzyme, which promotes smooth muscle relaxation in the penile vasculature and increases blood flow in response to sexual stimulation. Bremelanotide and pregnenolone belong to different pharmacological classes and are included to give your provider more than one mechanism to work with in a single preparation. Your protocol — the dose, the administration route, and the role each of the three compounds plays for you — is determined entirely by your licensed telehealth provider based on your individual health intake.

Tadalafil received FDA approval for erectile dysfunction in 2003 and belongs to the PDE5 inhibitor class, which has been studied in thousands of clinical trials across a broad range of patient populations. The citations below cover that component. Compounded multi-agent formulations allow licensed providers to prescribe combinations that aren't available in a single commercially manufactured product, and the supporting literature for the bremelanotide and pregnenolone components will be published here once the full formulation is confirmed by the pharmacy. This formulation, as prescribed through OLIV Well, is compounded at an FDA-registered, 503A-compliant pharmacy and is not the same as any commercially branded product.

This formulation contains a PDE5 inhibitor. Potential side effects common to that compound class include headache, flushing, nasal congestion, dyspepsia (indigestion), visual disturbances, and dizziness or lightheadedness. Serious but less common effects can include sudden vision or hearing loss and priapism — a prolonged, painful erection requiring immediate medical attention. PDE5 inhibitors are contraindicated in patients taking nitrates or alpha-blockers and in patients with certain cardiovascular conditions. This is not a complete list, and because the preparation carries two further actives the full profile is broader than the PDE5 class alone. Your OLIV Well provider will review your health history before prescribing, give you the complete side-effect and contraindication information for the exact preparation, and identify anything specific to your situation. Do not start this treatment without that evaluation.

Function: The PDE5 inhibitor component works by promoting vasodilation and supporting the physiological conditions required for erectile function in response to stimulation. Combining several compounds in one preparation allows your provider to calibrate the treatment to your individual response profile rather than prescribing a single fixed agent. Benefit: Sexual health is one of the most common — and least discussed — areas of men's health. Telehealth removes the conversation nobody wants to have in person, and gives you access to a clinically compounded treatment tailored to your situation by a real provider. The whole process stays private.