NAD+ Nasal Spray

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell in the body. It functions as a critical electron carrier in cellular energy metabolism — most notably within the mitochondria, where it plays a central role in the production of ATP, the body's primary energy currency. NAD+ also participates in DNA repair processes and in the activity of sirtuins, a class of proteins associated with cellular health and aging. NAD+ levels naturally decline with age, which is associated with reduced cellular energy output and increased susceptibility to cellular stress. Physician-prescribed NAD+ is intended to support cellular function by restoring or maintaining NAD+ availability. Delivered as a nasal spray for convenient at-home use, the specific formulation and dosing for your protocol are determined by your licensed OLIV Well provider.

Interest in NAD+ as a therapeutic target increased significantly following research in the early 2010s demonstrating the role of NAD+ precursors in extending healthspan in animal models. Studies using nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) — precursors to NAD+ — established that supplementation could raise intracellular NAD+ levels. Human clinical trials have since investigated NAD+ supplementation across a range of outcomes including metabolic function, cardiovascular health, and cognitive performance. The research base is still developing in some areas, but the underlying mechanism of NAD+ in cellular energy metabolism is well established. Physician-prescribed NAD+ through OLIV Well is compounded at FDA-registered, 503A-compliant facilities.

NAD+ is generally well-tolerated. Commonly reported effects include flushing or warmth, nasal or sinus irritation with the spray format, nausea or digestive discomfort, and fatigue or headache (typically transient, during early use). Serious adverse effects are uncommon but can occur. Individual responses vary. Your OLIV Well provider will review your health history before prescribing to determine whether NAD+ is appropriate and at what dose.

Function: NAD+ participates in oxidative phosphorylation — the mitochondrial process by which cells convert nutrients into usable energy. It also supports the activity of sirtuins and PARP enzymes, both involved in DNA maintenance and cellular stress response. Declining NAD+ levels with age are associated with reduced mitochondrial efficiency and a range of downstream cellular effects. Benefit: For adults focused on long-term health and performance, NAD+ addresses one of the most fundamental biological processes that changes with age. It's not a stimulant — it's cellular fuel. The goal is to support the systems that keep everything else running: energy, recovery, and cellular resilience.